I have always been enthusiastic about chemistry, physics and biology whilst at High School and was motivated to study for a degree in Biochemistry, Cell and Molecular Biology. After completing my graduate research thesis on “Drug Design for Diabetes” in Michigan-USA, I wanted to continue into post-graduate research in pharmacology and the molecular biosciences with the intention of progressing into a research related career. I am funded through the US Department of Education, a leading provider of funds for education for US citizens/permanent residents in the United States.
Our research group, under the supervision of Professor Andrew Munro, adopts an interdisciplinary approach towards tackling novel problems in drug design, metabolism and pharmacokinetics which interests me greatly.
The primary aim of my PhD project is to express, characterize, and find the substrates for the mycobacterium tuberculosis Cytochrome P450 isoforms (CYP141 and CYP144) as this will enable the development of novel drugs that inhibit these crucial enzymes important for the pathogenicity of the bacteria. This project combines the more traditional enzyme-kinetics style analysis, with the emerging fragment-based method for substrate development. This fragment-based method is in collaboration with Professor Chris Abel at The University of Cambridge and I particularly enjoy having the opportunity to work between institutions of such repute.
The city of Manchester caters for many of my personal interests, such as live music and sport, and I value the chance to join such a large post-graduate community and respected alumni. The city of Manchester houses almost every race and nationality in the world making it easier to find people with whom you share similar social interests!
“The quality and array of research and the support infrastructure was extremely attractive to me in selecting the MIB to continue my studies.”