Perspectives

'Realising Benefits from Synthetic Biology - from aspiration to commercial translation’, Dr Lionel Clarke.

Lionel is at the forefront of steering and developing SynBio for IB applications and has extensive knowledge and experience with applied biotechnology. Among other roles he is the Director of "Bio-Environmental Solutions" consulting on low-capex low-carbon energy and climate mitigation solutions, and co-Chairman of the UK Synthetic Biology Leadership Council (SBLC). Lionel is also a Honorary Chair in FLS, The Chairman of the External Advisory Board for our SYNBIOCHEM, a Visiting Professor in the Department of Bioengineering at Imperial College, London, and an EPSRC Engineering Strategic Advisory Team Member.

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'Realising Benefits from Synthetic Biology - from aspiration to commercial translation’- Dr Lionel Clarke The UK Synthetic Biology Roadmap provides a framework for this new technology to flourish

Although synthetic biology may be considered an emerging technology, its perceived potential to deliver valuable benefits is already generating keen interest to develop commercially-viable applications. The UK Synthetic Biology Roadmap sets out a vision for the sector, and provides a framework within which this technology can develop. In this presentation, Lionel explores the relationship between innovation and commercialization, and outline the need to take an integrated and holistic approach if anticipated benefits are to be effectively realized.

Lionel is at the forefront of steering and developing SynBio for IB applications and has extensive knowledge and experience with applied biotechnology. Among other roles he is the Director of "Bio-Environmental Solutions" consulting on low-capex low-carbon energy and climate mitigation solutions, and co-Chairman of the UK Synthetic Biology Leadership Council (SBLC). Lionel is also a Honorary Chair in FLS, The Chairman of the External Advisory Board for our SYNBIOCHEM, a Visiting Professor in the Department of Bioengineering at Imperial College, London, and an EPSRC Engineering Strategic Advisory Team Member.

Beilstein TV videos

We are delighted to highlight some videos filmed in the MIB by Beilstein TV. Beilstein TV is supporting the advancement of scientific communication by producing videos of research laboratory experiments, lectures and interviews with scientists. Their videos are adding important visual and verbal aspects to scientific publications. Science is not only about facts – it is also about the people. Scientists have opinions, they like or dislike a particular hypothesis, they differ in their expectations regarding the future of their research field. Statements and commentaries from scientists are made freely available to a wider audience by us.

Beilstein TV is funded by the Beilstein-Institut zur Förderung der Chemischen Wissenschaften (Beilstein Institute for the Advancement of Chemical Sciences) a Foundation established under civil law and located in Frankfurt am Main, Germany. The Beilstein-Institut was established as a non-profit organisation by the Max Planck Society in 1951. Communication and dissemination of information in the area of chemistry and related disciplines are at the centre of the Beilstein-Institut’s support activities.

The Beilstein-Institut fulfils its mission through its own long-term projects and by supporting individuals and institutions committed to advancing science throughout the world. The Beilstein Journal of Organic Chemistry and the Beilstein Journal of Nanotechnology are Open Access journals and are therefore freely available to all scientists worldwide. International symposia are organized where scientists from different disciplines can meet to exchange their knowledge. In research and education innovative projects are supported by the Beilstein-Institut either directly or through professorships and stipends.

Perspective on e-science, systems biology and drug discovery

Prof Douglas Kell talks about systems biology, computational aspects of biochemistry, and drug discovery, as well as open-access publishing and the communication of research results. The questions were prepared and asked by Prof Roy Goodacre.

Expanding the toolbox of cytochrome P450s through enzyme engineering

Turner Group

This video highlights the importance of cytochrome P450s in academia and industry and explains how our research group broadens the substrate range of these biocatalysts through enzyme engineering. We showcase a typical high-throughput assay and describe our procedure for carrying out whole-cell biotransformations.

Original research article:

Regio- and stereoselective oxidation of unactivated C–H bonds with Rhodococcus rhodochrous O’Reilly, E.; Aitken, S. J.; Grogan, G.; Kelly, P. P.; Turner, N. J.; Flitsch, S. L., Beilstein J. Org. Chem. 2012, 8, 496–500. doi:10.3762/bjoc.8.56 (hyperlink : http://www.beilstein-journals.org/bjoc/single/articleFullText.htm?publicId=1860-5397-8-56)

Chemical reactions on conducting surfaces

Flitsch Group

This video shows how we can achieve chemical and biochemical reactions on conducting surfaces and monitor these reactions in situ using MALDI-TOF mass spectrometry.

Original research article:

Formation of carbohydrate-functionalised polystyrene and glass slides and their analysis by MALDI-TOF MS Weissenborn, M. J.; Wehner, J. W.; Gray, C. J.; Šardzík, R.; Eyers, C. E.; Lindhorst, T. K.; Flitsch, S. L., Beilstein J. Org. Chem. 2012, 8, 753–762. doi:10.3762/bjoc.8.86 (hyperlink : http://www.beilstein-journals.org/bjoc/single/articleFullText.htm?publicId=1860-5397-8-86)

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