Biomolecular Mechanism & Catalysis

Research across the theme uses a diversity of structural, spectroscopic and computational techniques that are developed and used to study properties and the mechanistic details of biomolecular and biotechnological processes ranging from single proteins (enzymes) to macromolecular complexes and pathways.

It also creates novel components, devices and pathways that are utilised in Molecular Bioengineering.

Researchers aim at predicting the properties of large molecules by using quantum chemical information on small molecules. We aim to understand molecular and atomic properties that underpin biological function and to take these forward to inform molecular design.

Microbial cells and enzymes are employed in novel ways for the purpose, for example, of chemicals manufacturing, fuels and biotherapeutics etc, with emphasis on environmentally friendly methodology.

Research on the production of chemicals from renewable feedstocks focuses on enzyme-catalysed production of chemicals from lignin and integrated processes to produce high value chemicals directly from renewables using bio- and chemo-catalytic cascade reactions.

Manchester Centre for Biophysics and Catalysis (MCBC)

MCBC is home to a number of platform technologies in the biophysical and catalysis areas. We emphasize the integration of these technologies to address major biological challenges at the molecular level. This molecular insight is crucial in developing larger scale understanding of biology at the systems level. We also place emphasis on developing new technologies and the translation of molecular-based research.

Centre of Excellence in Biocatalysis, Biotransformation and Biocatalytic Manufacture (CoEBio3)

CoEBio3 undertakes cutting edge applied research in biocatalysis and metabolic engineering and serves to enhance UK competitiveness in R&D and manufacturing in biocatalysis. Other components of this initiative are satellite research facilities at the Universities of York, Strathclyde, Heriot-Watt and Glasgow, and an industrially focused, large-scale manufacturing facility at the Centre for Process Innovation in Wilton.

Biomolecular Mechanism and Catalysis Group leaders