MS is used for determining masses of particles, for determining the elemental composition of a sample or molecule, and for elucidating the chemical structures of molecules. It works by ionizing chemical compounds to generate charged molecules or molecule fragments and measuring their mass-to-charge ratios. The MIB hosts a wealth of capability in mass spectrometry.
Michael Barber Centre for Mass Spectrometry
Gas-phase ion chemistry research provides an enhanced understanding of the analytical techniques that underpin proteomics, metabolomics and the investigation of other molecules of biological significance. New developments in quantitative mass spectrometry provide much needed information for modeling of biological networks, while techniques are being developed for the analysis and quantification of a variety of post-translational modifications.
Mass spectrometric research has a long and rich history at The University of Manchester. In this network we attempt to bring together the experience and expertise of these researchers under one umbrella.
- Fast, simple and accurate sample confirmation
- Sample Accurate Mass determination
- Whole protein mass determination
- LC-MS fragment and component analysis
- Small molecule identification
- Confirm and analyze purity of sample mixtures
- Unknown sample identification
- Training and support for new users
Secondary Ion Mass Spectrometry (SIMS)
SIMS is developed and used for the analysis and imaging of chemical and biological systems, including advanced materials, single cells and biological tissue. The aims involve novel insights into the chemical and spacial organisation and function of these systems at the molecular level.
Nick Lockyer and John Vickerman are developing applications of SIMS in areas involving the characterisation and classification of cells and tissue at the molecular level. They are also working closely with industry to develop new instrumentation and analytical protocols to advance SIMS applications in biosciences.